QUININ SULFAT

Quinini sulfas

 

(C20H24N2O2)2. H2SO4. 2H2O P.t.l: 783,0

 

Quinin sulfat la (8S, 9R)-6-methoxycinchonan-9-ol sulfat (2 : 1) (muoi) dihydrat, phai cha t 99,0 en 101,0% (C20H24N2O2)2. H2SO4, tnh theo che pham a lam kho.

Tnh chat

Bot ket tinh trang hoac gan nh trang, hoac tinh the hnh kim khong mau, mn. Kho tan trong nc, hi tan trong nc soi va ethanol 96%, thc te khong tan trong ether.

nh tnh

A. Tien hanh phng phap sac ky lp mong (Phu luc 5.4).

Ban mong: Silica gel G (TT).

Dung moi khai trien: Diethylamin - ether toluen (10 : 24 : 40).

Dung dch th: Hoa tan 0,10 g che pham trong methanol (TT) va pha loang thanh 10 ml bang cung dung moi.

Dung dch oi chieu: Hoa tan 0,10 g quinin sulfat chuan (C) trong methanol (TT) va pha loang thanh 10 ml vi cung dung moi.

Cach tien hanh: Cham rieng biet len ban mong 5 ml moi dung dch tren. Trien khai sac ky en khi dung moi i c 15 cm, lay ban mong lam kho trong luong khong kh 15 phut va chay sac ky nhac lai. Sau o lam kho ban mong 105 oC trong 30 phut, e nguoi va phun thuoc th iodoplatinat (TT). Vet chnh tren sac ky o cua dung dch th phai tng t ve v tr, mau sac va kch thc so vi vet chnh cua dung dch oi chieu.

B. Hoa tan khoang 5 mg che pham trong 5 ml nc. Them 0,2 ml nc brom (TT) va 1 ml dung dch amoniac 2 M (TT), mau xanh luc xuat hien.

C. Hoa tan 0,1 g che pham trong 3 ml dung dch acid sulfuric 1 M (TT) va pha loang thanh 100 ml vi nc. Huynh quang mau xanh lam xuat hien khi quan sat di anh sang t ngoai 366 nm, va bien mat khi them 1 ml acid hydrocloric (TT).

D. Hoa tan khoang 45 mg che pham trong 5 ml dung dch acid hydrocloric loang (TT). Dung dch thu c cho phan ng A cua sulfat (Phu luc 8.1).

E. Che pham phai ap ng phep th pH (Phu luc 8.1)

o trong va mau sac cua dung dch

Dung dch S: Hoa tan 0,500 g che pham trong dung dch acid hydrocloric 0,1 M (TT) va pha loang thanh 25,0 ml vi cung dung moi.

Dung dch S phai trong (Phu luc 9.2) va khong c co mau am hn mau mau VL6 (Phu luc 9.3; phng phap 2).

pH

pH cua hon dch che pham 10 g/l trong nc t 5,7 en 6,6 (Phu luc 6.2).

Goc quay cc rieng

T -237 en -245o, tnh theo che pham a lam kho (Phu luc 6.4).

Xac nh tren dung dch S.

Cac alcaloid cinchona khac

Yeu cau va tien hanh th theo phep th Cac alcaloid cinchona khac trong chuyen luan Quinin hydroclorid.

Mat khoi lng do lam kho

T 3,0 en 5,0% (Phu luc 9.6).

(1,000 g; 105 oC).

Tro sulfat

Khong c qua 0,1% (Phu luc 9.9, phng phap 2).

Dung 1,0 g che pham.

nh lng

Hoa tan 0,300 g che pham trong hon hp gom 10 ml cloroform (TT) va 20 ml anhydrid acetic (TT). Chuan o bang dung dch acid percloric 0,1 N (C). Xac nh iem ket thuc bang phng phap chuan o o ien the (Phu luc 10.2).

1 ml dung dch acid percloric 0,1 N (C) tng ng vi 24,90 mg (C20H24N2O2)2. H2SO4.

Bao quan

Trong lo kn, tranh anh sang.

Loại thuốc

Tr sot ret.

Che pham

Vien nen.