NATRI THIOPENTAL VA NATRI CARBONAT  

Natrii thiopentalum et natrii carbonas

 

 

 

 

 


C11H17N2NaO2S P.t.l: 264,3

 

Natri thiopental va natri carbonat la hon hp cua natri (RS)-5-ethyl-5-(1-methylbutyl)-2-thiobarbiturat va natri carbonat khan, phai cha t 84,0 en 87,0% C11H17N2O2S va t 10,2 en 11,2% Na, ca hai eu tnh theo che pham a lam kho.

Tnh chat  

Bot trang hi nga, co mui giong nh toi, hut am.

De tan trong nc, tan mot phan trong ethanol 96%, thc te khong tan trong ether.

nh tnh  

Co the chon mot trong hai nhom nh tnh sau:

Nhom I: A, B, E.

Nhom II: A, C, D, E.

A. Acid hoa 10 ml dung dch S bang dung dch acid hydrocloric 7,3% (TT), dung dch sui bot. Lac dung dch nay vi 20 ml ether (TT) . Tach lay lp ether, ra vi 10 ml nc, lam khan bang natri sulfat khan (TT), loc. Lam bay hi dch loc en kho va say can 100 105 oC. Xac nh iem chay (Phu luc 6.7) cua can. Tron ong lng can nay vi thiopental chuan (C) va xac nh iem chay cua hon hp. iem chay cua can va cua hon hp phai khoang 160 oC. S khac biet ve iem chay cua 2 mau tren khong c qua 2 oC.

B. Pho hong ngoai (Phu luc 4.2) cua can thu c phep th A phai phu hp vi pho hong ngoai cua thiopental chuan (C).

C. Phng phap sac ky lp mong (Phu luc 5.4).

Ban mong: Silica gel GF254 (TT).

Dung moi khai trien: Amoniac am ac - ethanol 96% - cloroform (5 : 15 : 80).

Dung dch th: Hoa tan 0,1 g che pham trong nc va pha loang thanh 100 ml vi cung dung moi.

Dung dch oi chieu: Hoa tan 85 mg thiopental chuan (C) trong 10 ml dung dch natri hydroxyd 2 M (TT) va pha loang thanh 100 ml bang nc.

Cach tien hanh: Cham rieng biet len ban mong 10 ml moi dung dch tren. Trien khai sac ky en khi dung moi i c 18 cm. Quan sat ngay ban mong di anh sang t ngoai bc song 254 nm. Vet chnh tren sac ky o cua dung dch th phai giong ve v tr va kch thc vi vet chnh tren sac ky o cua dung dch oi chieu.

D. Che pham phai cho phan ng ac trng cua barbiturat co hydro nhom NH khong b thay the (Phu luc 8.1).

E. Phan ng A cua ion natri (Phu luc 8.1).

o trong va mau sac cua dung dch  

Dung dch S: Hoa tan 5,0 g che pham trong nc khong co carbon dioxyd (TT) va pha loang thanh 50 ml vi cung dung moi.

Dung dch S phai trong (Phu luc 9.2) va mau khong c am hn mau mau LV3 (Phu luc 9.3, phng phap 2).

Clorid  

Khong c qua 0,033% (Phu luc 9.4.5).

Lay 5 ml dung dch S, them 35 ml nc va 10 ml dung dch acid nitric 2 M (TT). Lac vi ether (TT) 3 lan, moi lan vi 25 ml. Bo lp ether, un cach thuy lp nc e loai hoan toan ether. Dung 15 ml lp nc nay e th.

Tap chat lien quan  

Xac nh bang phng phap sac ky lp mong (Phu luc 5.4).

Ban mong: Silica gel GF254 (TT).

Dung moi khai trien: Amoniac am ac - ethanol 96% - cloroform (5 : 15 : 80).

Dung dch th: Hoa tan 1,0 g che pham trong nc va pha loang thanh 100,0 ml vi cung dung moi, loc bo tua neu co.

Dung dch oi chieu: Pha loang 0,5 ml dung dch th thanh 100 ml bang nc.

Cach tien hanh: Cham rieng biet len ban mong 20 ml moi dung dch tren. Trien khai sac ky en khi dung moi i c khoang 15 cm. Quan sat ngay ban mong di anh sang t ngoai bc song 254 nm. Ngoai vet chnh, bat c vet phu nao tren sac ky o thu c t dung dch th khong c am mau hn vet tren sac ky o thu c t dung dch oi chieu (0,5%). Bo qua vet vach xuat phat.

Mat khoi lng do lam kho  

Khong c qua 2,5% (Phu luc 9.6).

(0,50 g; chan khong; 100 oC; 4 gi).

nh lng  

Natri: Hoa tan 0,400 g che pham trong 30 ml nc. Chuan o bang dung dch acid hydrocloric 0,1 N (C) va dung 0,1 ml dung dch o methyl (TT) lam ch th, en khi mau cua dung dch chuyen sang o. un soi nhe 2 phut, lam nguoi, neu can th tiep tuc chuan o bang dung dch acid hydrocloric 0,1 N (C) en mau o nh cu.

1 ml dung dch acid hydrocloric 0,1 N (C) tng ng vi 2,299 mg natri.

Thiopental: Hoa tan 0,150 g che pham trong 5 ml nc, them 2 ml dung dch acid sulfuric 1 M (TT) roi chiet vi cloroform (TT) 4 lan, moi lan 10 ml. Gop cac dch chiet cloroform lai, loc, ra pheu loc bang cloroform, gop dch loc, lam bay hi dch loc en kho tren cach thuy. Hoa tan can trong 30 ml dimethylformamid (TT) a c trung hoa trc bang dung dch lithi methoxyd 0,1 M (C), them 0,1 ml dung dch xanh thymol 0,2% trong methanol (TT). Chuan o ngay bang dung dch lithi methoxyd 0,1 M (C) en khi dung dch chuyen sang mau xanh l, tranh e dung dch tiep xuc vi carbon dioxyd cua khong kh trong suot qua trnh nh lng.

1 ml dung dch lithi methoxyd 0,1 M (C) tng ng vi 24,23 mg C11H18N2O2S.

Bao quan  

Trong chai lo kn va tranh anh sang.

Loai thuoc

Gay me.

Che pham  

Dung dch tiem thiopental.