NATRI CALCI EDETAT

Natrii calcii edetas

 

 

 

 

 

 

C10H12CaN2Na2O8. xH2O P.t.l: 374,3 (khan)

Natri calci edetat la dinatri [(ethylendinitrilo) tetra-acetato]calciat (2-) co cha mot lng khong xac nh nc ket tinh, phai cha t 98,0 en 102,0% C10H12CaN2Na2O8, tnh theo che pham khan.

Tnh chat

Bot trang hoac hau nh trang, de hut am. De tan trong nc, thc te khong tan trong ethanol 96% va ether.

nh tnh

A. Pho hong ngoai (Phu luc 4.2) cua che pham phai phu hp vi pho hong ngoai cua natri calci edetat chuan (ĐC).

B. Hoa tan 2 g che pham trong 10 ml nc, them 6 ml dung dch ch nitrat (TT), lac va them 3 ml dung dch kali iodid (TT), khong c co tua mau vang xuat hien. Kiem hoa dung dch tren bang cach them dung dch amoniac 2 M (TT), dung giay quy o lam ch th va them 3 ml dung dch amoni oxalat 4% (TT), se co tua trang.

C. Hoa tan 0,5 g che pham trong 10 ml nc. Kiem hoa dung dch bang cach them dung dch amoniac 2 M (TT), dung giay quy o lam ch th va them 3 ml dung dch amoni oxalat 4% (TT). Toi a ch co tua nhe hnh thanh.

D. Nung che pham. Can cho phan ng ac trng cua ion calci va ion natri (Phu luc 8.1).

o trong va mau sac cua dung dch

Dung dch S: Hoa tan 5,0 g che pham trong nc va pha loang thanh 100,0 ml với cung dung moi.

Dung dch S phai trong (Phu luc 9.2) va khong mau (Phu luc 9.3, phng phap 2).

pH

Hoa tan 5,0 g che pham trong nc khong co carbon dioxyd (TT) va pha loang thanh 25,0 ml với cung dung moi. pH cua dung dch t 6,5 en 8,0 (Phu luc 6.2).

Dinatri edetat

Khong c qua 1,0%.

Hoa tan 5,0 g che pham trong 250 ml nc. Them 10 ml dung dch em amoniac pH 10,0 (TT) va khoang 50 mg hon hp en eriocrom T (TT). Lng dung dch magnesi clorid 0,1 M (C) dung e lam thay oi mau cua ch th thanh mau tm khong c qua 1,5 ml.

Clorid

Khong c qua 0,1% (Phu luc 9.4.5).

Them 30 ml dung dch acid nitric loang (TT) vao 20 ml dung dch S, e yen 30 phut va loc. Lay 2,5 ml dch loc pha loang vi nc thanh 15 ml e tien hanh th.

Kim loai nang

Khong c qua 20 phan trieu (Phu luc 9.4.8).

Lay 1,0 g che pham tien hanh th theo phng phap 4. Dung 2 ml dung dch ch mau 10 phan trieu (TT) e chuan b mau oi chieu.

Sat

Khong c qua 80 phan trieu (Phu luc 9.4.13).

Lay 2,5 ml dung dch S, pha loang vi nc thanh 10,0 ml va tien hanh th. Them 0,25 g calci clorid (TT) vao moi ong trc khi them acid mercaptoacetic (TT).

Nc

T 5,0 en 13,0% (Phu luc 10.3).

Dung 0,100 g che pham e th.

nh lng

Hoa tan 0,500 g che pham trong 300 ml nc, them 2 g hexamethylentetramin (TT) va 2 ml dung dch acid hydrocloric loang (TT). Chuan o bang dung dch ch nitrat 0,1 M (C), dung khoang 50 mg hon hp da cam xylenol (TT) lam ch th.

1 ml dung dch ch nitrat 0,1 M (C) tng ng vi 37,43 mg C10H12CaN2Na2O8.

Bao quan

Trong lo nut kn.

Loi thuc

Lam chat tao phc ieu tr ngo oc ch.