CODEIN

Codeinum monohydricum

Codein monohydrat

 

 

 

 

 

 


C18H21NO3. H2O P.t.l: 317,4

Codein la 4,5a-epoxy-3-methoxy-17-methyl-7,8-didehydromorphinan-6a-ol, monohydrat phai cha t 99,0 en 101,0% C18H21NO3, tnh theo che pham a lam kho.

Tnh chat

Tinh the khong mau hoac bot ket tinh trang, khong mui.

De tan trong cloroform va ethanol 96%, tan trong nc soi va trong ether, kho tan trong nc.

nh tnh

Co the chon mot trong 2 nhom nh tnh sau:

Nhom I: A, C.

Nhom II: B, C, D, E.

A. Pho hong ngoai (Phu luc 4.2) cua che pham phai phu hp vi pho hong ngoai oi chieu cua codein chuan (C). Phep th c tien hanh tren che pham a lam kho.

B. Them vao 2,0 ml dung dch S 50 ml nc va 10 ml dung dch natri hydroxyd 1 M (TT), pha loang thanh 100,0 ml bang nc. o pho t ngoai (Phu luc 4.1) cua dung dch tren dai song t 250 en 350 nm. Dung dch ch co duy nhat mot cc ai hap thu 284 nm. o hap thu rieng bc song cc ai khoang 50, tnh theo che pham a lam kho.

C. iem chay: 155 en 159 oC (Phu luc 6.7).

D. Them 1 ml acid sulfuric (TT) va 0,05 ml dung dch sat (III) clorid 1,3% (TT) vao khoang 10 mg che pham va un nong tren cach thuy, se xuat hien mau xanh lam. Them 0,05 ml acid nitric (TT), mau chuyen sang o.

E. Che pham cho phan ng cua cac alcaloid (Phu luc 8.1).

o trong va mau sac cua dung dch

Dung dch S: Hoa tan 50 mg che pham trong nc khong co carbon dioxyd (TT) va pha loang thanh 10 ml bang cung dung moi.

Dung dch S phai trong (Phu luc 9.2) va khong mau (Phu luc 9.3, phng phap 2).

pH

pH cua dung dch S phai ln hn 9 (Phu luc 6.2).

Goc quay cc rieng

T -142o en -146o, tnh theo che pham a lam kho (Phu luc 6.4).

Hoa tan 0,50 g che pham trong ethanol 96% (TT) va pha loang thanh 25,0 ml bang cung dung moi e o.

Morphin

Khong c qua 0,13%.

Hoa tan 0,10 g che pham trong dung dch acid hydrocloric 0,1 N (TT) va pha loang thanh 5 ml vi cung dung moi. Them 2 ml dung dch natri nitrit 1% (TT), e yen 15 phut va them 3 ml dung dch amoniac 6 M (TT). Mau cua dung dch thu c khong c am hn mau mau N4 (Phu luc 9.3, phng phap 2).

Alcaloid la

Xac nh bang phng phap sac ky lp mong (Phu luc 5.4).

Ban mong: Silica gel G.

Dung moi khai trien: Amoniac am ac - cyclohexan - ethanol (6 : 30 : 72).

Dung dch th: Hoa tan 0,400 g che pham trong ethanol (TT) va pha loang thanh10 ml bang cung dung moi.

Dung dch oi chieu (1): Pha loang 1,5 ml dung dch th thanh 100 ml bang ethanol (TT)

Dung dch oi chieu (2): Pha loang 1 ml dung dch th thanh 100 ml bang ethanol (TT).

Cach tien hanh: Cham rieng biet len ban mong 10 ml moi dung dch tren. Trien khai sac ky en khi dung moi i c khoang 15 cm, lay ban mong ra e kho ngoai khong kh va phun dung dch kali iodobismuthat (TT). Tren sac ky o, ngoai vet chnh, bat ky vet phu nao cua dung dch th eu khong c am mau hn vet cua dung dch oi chieu (1) ( 1,5%) va ch c mot vet ( pha tren vet chnh) am mau hn vet cua dung dch oi chieu (2) (1,0%).

Mat khoi lng do lam kho

T 5,0 en 6,0% (Phu luc 9.6).

(1,00 g; 100 105 oC).

Tro sulfat

Khong c qua 0,1% (Phu luc 9.9, phng phap 2).

Dung 1,0 g che pham.

nh lng

Hoa tan 0,250 g che pham trong 30 ml acid acetic khan (TT), them 20 ml dioxan (TT) va 4 giot dung dch tm tinh the (TT). Chuan o bang dung dch acid percloric 0,1 N (C). Song song lam mau trang.

1 ml dung dch acid percloric 0,1 N (C) tng ng vi 29,94 mg C18H21NO3.

Bao quan

Trong bnh kn tranh anh sang.

Loại thuốc

Giam au, chong ho, tr tieu chay.

Che pham

Vien nen codein. Vien codein - terpin hydrat, vien codein - natribenzoat.